StressCovidV1, Main, Exploration, bibRecord, 001D20

A TRIFfic perspective on acute lung injury.

Identifieur interne : 001D20 ( Main/Exploration ); précédent : 001D19; suivant : 001D21

A TRIFfic perspective on acute lung injury.

Auteurs : Thomas R. Martin [États-Unis] ; Mark M. Wurfel

Source :

Cell [ 1097-4172 ] ; 2008.

RBID : pubmed:18423191

Descripteurs français

KwdFr :
- Animaux, Humains, Phospholipides (métabolisme), Protéines adaptatrices du transport vésiculaire (métabolisme), Récepteur de type Toll-4 (métabolisme), Souris, Stress oxydatif, Syndrome de détresse respiratoire de l'adulte (métabolisme).
MESH :
- métabolisme : Phospholipides, Protéines adaptatrices du transport vésiculaire, Récepteur de type Toll-4, Syndrome de détresse respiratoire de l'adulte.
- Animaux, Humains, Souris, Stress oxydatif.

English descriptors

KwdEn :
- Adaptor Proteins, Vesicular Transport (metabolism), Animals, Humans, Mice, Oxidative Stress, Phospholipids (metabolism), Respiratory Distress Syndrome, Adult (metabolism), Toll-Like Receptor 4 (metabolism).
MESH :
- chemical , metabolism : Adaptor Proteins, Vesicular Transport, Phospholipids, Toll-Like Receptor 4.
- metabolism : Respiratory Distress Syndrome, Adult.
- Animals, Humans, Mice, Oxidative Stress.

Abstract

Acute lung injury (ALI) is a leading cause of death in people infected with H5N1 avian influenza virus or the SARS-coronavirus. Imai et al. (2008) now report that ALI is triggered by the signaling of oxidized phospholipids through Toll-like receptor 4 (TLR4) and the adaptor protein TRIF. These findings provide insight into the molecular pathogenesis of ALI, a condition for which treatment options are currently very limited.

DOI: 10.1016/j.cell.2008.04.006
PubMed: 18423191

Affiliations:

Le document en format XML

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<author><name sortKey="Martin, Thomas R" sort="Martin, Thomas R" uniqKey="Martin T" first="Thomas R" last="Martin">Thomas R. Martin</name>
<affiliation wicri:level="4"><nlm:affiliation>The Medical Research Service of the VA Puget Sound Health Care System and the Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington, Seattle, WA 98108, USA. trmartin@u.washington.edu</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Medical Research Service of the VA Puget Sound Health Care System and the Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington, Seattle, WA 98108</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
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<orgName type="university">Université de Washington</orgName>
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<author><name sortKey="Wurfel, Mark M" sort="Wurfel, Mark M" uniqKey="Wurfel M" first="Mark M" last="Wurfel">Mark M. Wurfel</name>
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<affiliation wicri:level="4"><nlm:affiliation>The Medical Research Service of the VA Puget Sound Health Care System and the Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington, Seattle, WA 98108, USA. trmartin@u.washington.edu</nlm:affiliation>
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<series><title level="j">Cell</title>
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<term>Oxidative Stress</term>
<term>Phospholipids (metabolism)</term>
<term>Respiratory Distress Syndrome, Adult (metabolism)</term>
<term>Toll-Like Receptor 4 (metabolism)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
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<term>Phospholipides (métabolisme)</term>
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<term>Récepteur de type Toll-4 (métabolisme)</term>
<term>Souris</term>
<term>Stress oxydatif</term>
<term>Syndrome de détresse respiratoire de l'adulte (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Adaptor Proteins, Vesicular Transport</term>
<term>Phospholipids</term>
<term>Toll-Like Receptor 4</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Respiratory Distress Syndrome, Adult</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Phospholipides</term>
<term>Protéines adaptatrices du transport vésiculaire</term>
<term>Récepteur de type Toll-4</term>
<term>Syndrome de détresse respiratoire de l'adulte</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Humans</term>
<term>Mice</term>
<term>Oxidative Stress</term>
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<front><div type="abstract" xml:lang="en">Acute lung injury (ALI) is a leading cause of death in people infected with H5N1 avian influenza virus or the SARS-coronavirus. Imai et al. (2008) now report that ALI is triggered by the signaling of oxidized phospholipids through Toll-like receptor 4 (TLR4) and the adaptor protein TRIF. These findings provide insight into the molecular pathogenesis of ALI, a condition for which treatment options are currently very limited.</div>
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<tree><noCountry><name sortKey="Wurfel, Mark M" sort="Wurfel, Mark M" uniqKey="Wurfel M" first="Mark M" last="Wurfel">Mark M. Wurfel</name>
</noCountry>
<country name="États-Unis"><region name="Washington (État)"><name sortKey="Martin, Thomas R" sort="Martin, Thomas R" uniqKey="Martin T" first="Thomas R" last="Martin">Thomas R. Martin</name>
</region>
</country>
</tree>
</affiliations>
</record>

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Serveur d'exploration Stress et Covid

A TRIFfic perspective on acute lung injury.

A TRIFfic perspective on acute lung injury.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration Stress et Covid
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